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News items on 'Tamoxifen'
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Breast drug failure cause found
(BBC 13/11/2008)
In this study, involving 100 breast cancer patients, the Cancer Research UK Cambridge Research Institute found tamoxifen works by switching off the breast cancer gene HER2 via a protein called PAX2. In patients receiving tamoxifen treatment, the highest levels of PAX2 were associated with improved survival. In contrast, tumours resistant to the drug had higher levels of another molecule, AIB-1.
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